Antifolate

Term: AntifolateDefinition: Antifolates are a class of chemotherapy drugs that inhibit the action of folic acid, used in the treatment of various cancers including mesothelioma caused by asbestos exposure.Phonetic Pronunciation: (an-tee-FOH-layt)Origin: The term "antifolate" is derived from the combination of "anti-", meaning against or opposed to, and "folate", which refers to a form of vitamin B9. The concept and terminology emerged in the mid-20th century as part of cancer research and chemotherapy development.Significance in Asbestos Context: Antifolates are significant in the treatment of asbestos-related diseases like mesothelioma. They are used to slow the growth of cancer cells by disrupting DNA synthesis, offering a therapeutic option for patients affected by asbestos exposure.Example Sentence: After being diagnosed with mesothelioma due to asbestos exposure, the patient started a treatment regimen that included the antifolate drug pemetrexed.Related Terms: Chemotherapy, Mesothelioma, Pemetrexed, Folate, DNA SynthesisNotes: - Antifolates can have significant side effects and their use should be closely monitored by healthcare professionals. - Pemetrexed is a commonly used antifolate in the treatment of mesothelioma. - Antifolates are not a cure but can help manage the disease and improve quality of life.