Term: BAP1 (BRCA1-Associated Protein 1)
Definition: BAP1 is a tumor suppressor gene that produces a protein involved in regulating cell growth and DNA repair. Mutations in this gene are associated with an increased risk of certain cancers, including mesothelioma.
Phonetic Pronunciation: (BEE-ay-pee-wun)
Etymological Origin: The term "BAP1" is an acronym for "BRCA1-Associated Protein 1." It reflects the gene's initial identification as a protein interacting with BRCA1, another tumor suppressor gene. The name originates from molecular biology research into cancer genetics.
Significance in Asbestos Context: BAP1 is significant in the field of asbestos because mutations in this gene are linked to a predisposition to mesothelioma, a cancer caused by asbestos exposure. Individuals with a BAP1 mutation may develop mesothelioma even with lower levels of asbestos exposure compared to the general population. This has implications for understanding genetic susceptibility, early detection, and potential legal considerations in asbestos-related litigation.
Synonyms or Related Terms: Tumor suppressor gene, mesothelioma susceptibility gene, BRCA1-associated protein.
Example Sentence: "Research has shown that individuals with a BAP1 mutation are more likely to develop mesothelioma after asbestos exposure, highlighting the role of genetics in asbestos-related diseases."
Common Misconceptions:
