BAP1

Term: BAP1Definition: BAP1 is a tumor suppressor gene that, when mutated, increases the risk of developing mesothelioma and other cancers. Mutations in BAP1 can be inherited, leading to a higher susceptibility to asbestos-related diseases.Phonetic Pronunciation: (BAP-one)Origin: BAP1 stands for BRCA1-associated protein-1, named due to its interaction with the BRCA1 protein, which is known for its role in breast cancer. The gene was first identified in the late 1990s, and its significance in cancer research has grown over the years, particularly in relation to asbestos-related diseases.Significance in Asbestos Context: BAP1 mutations are significant in the context of asbestos exposure because individuals with these mutations are at a higher risk of developing mesothelioma upon exposure to asbestos. This genetic factor can influence the legal strategies in asbestos litigation, as it may affect the assessment of liability and compensation.Example Sentence: "The plaintiff's increased susceptibility to mesothelioma due to a BAP1 mutation was a key factor in the asbestos exposure lawsuit."Related Terms: Mesothelioma, Asbestos Exposure, Tumor Suppressor Gene, Genetic Mutation, BRCA1Notes: - BAP1 mutations do not guarantee the development of cancer but increase the risk. - Genetic testing can identify BAP1 mutations, which can be crucial in legal cases involving asbestos exposure.