BRAF V600E

Term: BRAF V600EDefinition: A specific mutation in the BRAF gene, resulting in a change from valine (V) to glutamic acid (E) at position 600, which can lead to uncontrolled cell growth and is associated with various cancers.Phonetic Pronunciation: (BEE-RAF VEE-six-hundred-EE)Origin: The term "BRAF" is derived from "B-Raf," a protein in the Raf kinase family, which is part of the MAPK/ERK signaling pathway. The "V600E" refers to the specific mutation at the 600th amino acid position, where valine is replaced by glutamic acid. The nomenclature follows the standard genetic mutation naming convention.Significance in Asbestos Context: While not directly linked to asbestos exposure, understanding the BRAF V600E mutation is crucial in oncology, as it can influence the development of certain cancers, including those that may be associated with asbestos exposure. This mutation can affect treatment strategies and prognosis for asbestos-related malignancies.Example Sentence: The presence of the BRAF V600E mutation in a patient's mesothelioma tumor may influence the choice of targeted therapies.Related Terms: Mutation, Oncogene, Targeted Therapy, Mesothelioma, Lung CancerNotes: - BRAF V600E is more commonly associated with melanoma but can occur in other cancers. - The mutation's presence can be detected through genetic testing, which is important for personalized medicine approaches.