CA-125

Type: Medical Term

Term: CA-125 (Cancer Antigen 125)

Definition: CA-125 is a protein found in the blood that is often elevated in individuals with certain cancers, particularly ovarian cancer. It is used as a biomarker to monitor disease progression or response to treatment.

Phonetic Pronunciation: (see-ay-wun-twen-tee-five)

Etymological Origin: The term "CA-125" originates from its identification as a cancer-associated antigen (CA) during research into tumor markers. The number "125" refers to the specific monoclonal antibody used to detect this antigen.

Significance in Asbestos Context: CA-125 is significant in the asbestos field because it can sometimes be elevated in individuals with mesothelioma, a cancer caused by asbestos exposure. While not specific to mesothelioma, CA-125 may be used as part of a panel of biomarkers to assess disease activity or progression in asbestos-related cancers.

Synonyms or Related Terms: Tumor marker, cancer antigen, biomarker for ovarian cancer.

Example Sentence: "In some cases of mesothelioma, CA-125 levels may be elevated, although it is not a definitive diagnostic marker for asbestos-related diseases."

Common Misconceptions:

  1. Misconception: CA-125 is specific to mesothelioma.
    Clarification: CA-125 is not specific to mesothelioma and is more commonly associated with ovarian cancer. Its elevation in mesothelioma is less frequent and not diagnostic.
  2. Misconception: Elevated CA-125 always indicates cancer.
    Clarification: CA-125 can also be elevated in non-cancerous conditions, such as endometriosis or inflammation, and should not be used alone for diagnosis.
  3. Misconception: CA-125 is a reliable screening tool for asbestos-related diseases.
    Clarification: CA-125 is not a reliable screening tool for asbestos-related diseases and is primarily used for monitoring known cancers.