Definition:
Circulating tumor DNA (ctDNA) refers to small fragments of DNA that are released into the bloodstream by cancer cells as they die. These fragments can be detected and analyzed to provide information about the genetic makeup of a tumor.
Phonetic Pronunciation:
(ser-kyoo-LAY-ting TOO-mer DEE-ehn-AY)
Etymological Origin:
The term "circulating" is derived from the Latin word "circulare," meaning "to move in a circle," referring to the movement of substances through the bloodstream. "Tumor" comes from the Latin "tumor," meaning "swelling," and "DNA" is an abbreviation for deoxyribonucleic acid, the molecule that carries genetic information.
Significance in Asbestos Context:
ctDNA is significant in the field of asbestos-related diseases, particularly in the diagnosis and monitoring of cancers such as mesothelioma and lung cancer, which are associated with asbestos exposure. By analyzing ctDNA, clinicians can identify specific genetic mutations or biomarkers linked to these cancers, enabling early detection, personalized treatment plans, and monitoring of disease progression or response to therapy. This non-invasive method is especially valuable for patients with asbestos-related malignancies, as it reduces the need for invasive biopsies.
Synonyms or Related Terms:
Example Sentence:
"The detection of ctDNA in the blood of patients exposed to asbestos has shown promise in identifying early genetic changes associated with mesothelioma."
Common Misconceptions:
