Definition:
D2-40 (Podoplanin) is a protein expressed on the surface of certain cells, including lymphatic endothelial cells, and is commonly used as an immunohistochemical marker to identify lymphatic vessels and specific tumors, such as mesothelioma.
Phonetic Pronunciation:
(Dee-too-FOUR-tee) or (Poh-doh-PLAH-nin)
Etymological Origin:
The term "D2-40" refers to the specific monoclonal antibody used to detect podoplanin, a protein whose name is derived from its resemblance to "podocytes" (cells with foot-like projections) and its role in lymphatic and tumor biology. The name "podoplanin" combines the Greek word podos (foot) and planos (wandering or flat).
Significance in Asbestos Context:
D2-40 (Podoplanin) is significant in the asbestos context because it is a key diagnostic tool in identifying malignant mesothelioma, a cancer strongly associated with asbestos exposure. Pathologists use D2-40 in immunohistochemical staining to differentiate mesothelioma from other types of cancer, such as adenocarcinoma, which is critical for accurate diagnosis, treatment planning, and litigation related to asbestos exposure.
Synonyms or Related Terms:
Example Sentence:
"The use of D2-40 staining helped confirm the diagnosis of malignant mesothelioma in the patient, who had a history of prolonged asbestos exposure."
Common Misconceptions:
