DNA adducts

Term: DNA adductsDefinition: Chemical modifications to DNA that can result from exposure to asbestos fibers, potentially leading to mutations and cancer.Phonetic Pronunciation: (dee-en-ay AD-dukts)Origin: The term "DNA" comes from the English abbreviation of Deoxyribonucleic Acid. "Adduct" derives from the Latin word "adductus," meaning "drawn toward," reflecting the chemical attachment to the DNA molecule.Significance in Asbestos Context: DNA adducts are significant in asbestos-related research because they provide a molecular mechanism by which asbestos exposure can lead to genetic damage and subsequent diseases such as mesothelioma and lung cancer. Understanding these adducts helps in assessing the risk and progression of asbestos-related illnesses.Example Sentence: "Research has shown that asbestos exposure can lead to the formation of DNA adducts, increasing the risk of developing asbestos-related cancers."Related Terms: Mutagenesis, Carcinogenesis, Asbestos Exposure, Mesothelioma, Lung CancerNotes: - DNA adducts are not unique to asbestos exposure but can be caused by various environmental and chemical agents. - The presence of DNA adducts is an indicator of potential genetic damage, but not all adducts will necessarily lead to disease.