Definition: The extracellular matrix (ECM) is a complex network of proteins, glycoproteins, and other molecules that provide structural and biochemical support to surrounding cells in tissues.
Phonetic Pronunciation: (EKS-truh-SEL-yoo-lur MAY-triks)
Etymological Origin:
The term "extracellular matrix" is derived from Latin: extra (meaning "outside"), cellular (referring to cells), and matrix (meaning "womb" or "framework"). It reflects the ECM's role as a supportive framework outside the cells.
Significance in Asbestos Context:
The extracellular matrix is significant in the context of asbestos exposure because it plays a critical role in tissue repair and fibrosis. When asbestos fibers are inhaled, they can damage lung tissue, triggering an inflammatory response. This response often leads to the overproduction of ECM components, such as collagen, resulting in fibrosis (scarring) of the lungs, as seen in asbestosis. Additionally, changes in the ECM can influence the progression of mesothelioma and other asbestos-related cancers by affecting cell behavior and tumor growth.
Synonyms or Related Terms:
Example Sentence: The accumulation of collagen in the extracellular matrix is a hallmark of asbestosis, a chronic lung disease caused by prolonged asbestos exposure.
Common Misconceptions:
This explanation highlights the importance of the extracellular matrix in understanding the biological effects of asbestos exposure and its role in the development of related diseases.
