Fluorouracil (5-FU)

Term: Fluorouracil (5-FU)Definition: Fluorouracil, commonly known as 5-FU, is a chemotherapy drug used in the treatment of various cancers, including those related to asbestos exposure such as mesothelioma.Phonetic Pronunciation: (flure-oh-URE-uh-sil)Origin: The term 'Fluorouracil' is derived from its chemical structure, which includes a fluorine atom and uracil, a component of RNA. The '5-FU' abbreviation indicates that the fluorine atom is attached at the fifth position of the uracil molecule. The name reflects the drug's synthetic origin, developed in the 1950s by Charles Heidelberger and his team.Significance in Asbestos Context: Fluorouracil is significant in the treatment of asbestos-related diseases, particularly mesothelioma. It is often used in combination with other chemotherapy agents to improve the effectiveness of cancer treatment in patients exposed to asbestos.Example Sentence: "The oncologist recommended a regimen of Fluorouracil (5-FU) for the patient diagnosed with mesothelioma due to asbestos exposure."Related Terms: Chemotherapy, Mesothelioma, Asbestos-related cancer, Pemetrexed, CisplatinNotes: - Fluorouracil is not a cure for asbestos-related diseases but can help manage symptoms and extend life expectancy. - Side effects of 5-FU can include nausea, diarrhea, and skin reactions, which should be monitored closely. - The effectiveness of Fluorouracil can vary depending on the stage and type of cancer.