Definition:
HMGB1 (High Mobility Group Box 1) is a protein that plays a role in DNA organization and repair, as well as in the regulation of inflammation and immune responses. It is released by damaged or dying cells and acts as a signal to the immune system.
Phonetic Pronunciation:
(HIGH-moh-BIL-ih-tee GROOP BOKS wun)
Etymological Origin:
The term "HMGB1" originates from its classification as part of the "High Mobility Group" of proteins, named for their ability to move rapidly during electrophoresis due to their small size and high charge. The "Box 1" refers to a specific structural domain within the protein.
Significance in Asbestos Context:
HMGB1 is significant in the context of asbestos exposure because it has been identified as a key mediator in the development of mesothelioma, a cancer caused by asbestos. When asbestos fibers damage mesothelial cells, HMGB1 is released, triggering chronic inflammation and promoting tumor growth. This protein is also being studied as a potential biomarker for early detection of mesothelioma and as a target for therapeutic interventions.
Synonyms or Related Terms:
Example Sentence:
"Research has shown that HMGB1 plays a critical role in the inflammatory response triggered by asbestos exposure, contributing to the development of mesothelioma."
Common Misconceptions:
