Macrophage

Term: MacrophageDefinition: A type of white blood cell that engulfs and digests cellular debris, foreign substances, and pathogens.Phonetic Pronunciation: (MAK-roh-fayj)Origin: The term "macrophage" comes from the Greek words "makros," meaning large, and "phagein," meaning to eat. It was coined in the late 19th century to describe these large immune cells that consume other cells and particles.Significance in Asbestos Context: Macrophages play a critical role in the body's response to asbestos fibers. When asbestos is inhaled, macrophages attempt to engulf and remove the fibers, but their efforts can lead to inflammation and further cellular damage, contributing to asbestos-related diseases.Example Sentence: In cases of asbestos exposure, macrophages can become overwhelmed and damaged as they try to clear asbestos fibers from the lungs.Related Terms: Phagocytosis, Inflammation, Asbestosis, Immune Response, Alveolar MacrophageNotes: - Macrophages are part of the innate immune system. - Their role in asbestos-related diseases can lead to chronic inflammation and fibrosis. - Macrophages can also release cytokines, which further amplify the inflammatory response.