MET exon 14 skipping

Term: MET exon 14 skippingDefinition: A genetic alteration in the MET gene that leads to the skipping of exon 14 during RNA splicing, resulting in an altered MET protein with increased activity.Phonetic Pronunciation: (MET ek-SON fourteen SKIP-ing)Origin: The term "MET" derives from "met proto-oncogene," which was named after its discovery in a chemically-induced osteosarcoma in a mouse. "Exon" comes from "expressed region," referring to the coding sections of genes. "Skipping" in this context refers to the omission of a segment during gene expression, a term borrowed from everyday language.Significance in Asbestos Context: MET exon 14 skipping is significant in asbestos-related diseases because it is associated with an increased risk of developing lung cancer, particularly in individuals exposed to asbestos. This genetic alteration can be targeted with specific therapies, offering potential treatment options for affected individuals.Example Sentence: Recent research has shown that patients with asbestos exposure who also have MET exon 14 skipping may benefit from targeted therapies that inhibit the MET pathway.Related Terms: MET gene, lung cancer, targeted therapy, RNA splicing, oncogene.Notes: - MET exon 14 skipping is not exclusive to asbestos exposure but can be more prevalent in asbestos-related lung cancers. - It is important to test for this mutation in patients with a history of asbestos exposure to tailor treatment plans effectively.