Nuclear Factor kappa B (NF-κB)

Term: Nuclear Factor kappa B (NF-κB)Definition: A protein complex that controls DNA transcription, cytokine production, and cell survival, which is implicated in the inflammatory response to asbestos exposure.Phonetic Pronunciation: (NOO-klee-er FAK-tor KAP-pa BEE)Origin: The term "Nuclear Factor kappa B" derives from its discovery as a factor that binds to the kappa light-chain enhancer in B cells. The name reflects its role in nuclear activity and its initial identification in B lymphocytes. The term "kappa" comes from the Greek letter κ (kappa), used in the scientific naming convention to denote a specific type of immunoglobulin light chain.Significance in Asbestos Context: NF-κB plays a critical role in the cellular response to asbestos fibers, as its activation can lead to chronic inflammation and the development of asbestos-related diseases such as mesothelioma and lung cancer. Understanding the pathways involving NF-κB can provide insights into the mechanisms of asbestos toxicity and potential therapeutic targets.Example Sentence: Research has shown that exposure to asbestos can lead to the activation of NF-κB, contributing to the inflammatory processes that precede the development of mesothelioma.Related Terms: Inflammation, Mesothelioma, Cytokine, DNA Transcription, Cell SurvivalNotes: - NF-κB is not unique to asbestos exposure but is involved in many inflammatory and immune responses. - The activation of NF-κB can be influenced by various external stimuli beyond asbestos. - Inhibiting NF-κB pathways is a potential area of research for treating asbestos-related diseases.