Oncogenesis

Term: OncogenesisDefinition: The process by which normal cells are transformed into cancer cells, often involving genetic mutations and cellular changes.Phonetic Pronunciation: (ong-koh-JEN-uh-sis)Origin: The term 'oncogenesis' is derived from the Greek words 'onkos,' meaning 'mass' or 'tumor,' and 'genesis,' meaning 'origin' or 'creation.' It reflects the concept of the origin of tumors, which has been a focus of medical research for centuries.Significance in Asbestos Context: Oncogenesis is crucial in understanding how asbestos exposure can lead to the development of cancers such as mesothelioma and lung cancer. Asbestos fibers can cause genetic damage and cellular changes that initiate the oncogenic process, making it a key mechanism in asbestos-related diseases.Example Sentence: Research has shown that the inhalation of asbestos fibers can trigger oncogenesis, leading to the development of malignant mesothelioma in exposed individuals.Related Terms: Carcinogenesis, Tumorigenesis, Mesothelioma, Lung Cancer, Genetic MutationNotes: - Oncogenesis is not a disease itself but a process that can lead to various types of cancer. - The link between asbestos and oncogenesis is well-established, but the exact mechanisms are still under investigation. - Preventing exposure to asbestos is crucial in reducing the risk of oncogenesis.