Definition:
Oxidative stress is a condition that occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body's ability to neutralize them with antioxidants, leading to cellular and tissue damage.
Phonetic Pronunciation:
(ahk-sih-DAY-tiv stress)
Etymological Origin:
The term "oxidative" comes from the Latin word "oxidare," meaning "to oxidize" or "to combine with oxygen," and "stress" originates from the Middle English word "stresse," meaning "hardship" or "pressure." Together, the term refers to the harmful effects caused by excessive oxidation in biological systems.
Significance in Asbestos Context:
Oxidative stress is highly relevant in the context of asbestos exposure because asbestos fibers can generate reactive oxygen species (ROS) and reactive nitrogen species (RNS) through various mechanisms, such as iron-catalyzed reactions and activation of inflammatory cells. This oxidative damage contributes to the development of asbestos-related diseases, including asbestosis, lung cancer, and mesothelioma. Understanding oxidative stress is crucial for studying the pathogenesis of these diseases and exploring potential therapeutic interventions.
Synonyms or Related Terms:
Example Sentence:
"Research has shown that oxidative stress plays a central role in the cellular damage caused by asbestos fibers, leading to chronic inflammation and the development of mesothelioma."
Common Misconceptions:
