p53

Term: p53Definition: A tumor suppressor gene that plays a crucial role in preventing cancer formation by regulating cell division and apoptosis.Phonetic Pronunciation: (pee-fifty-three)Origin: The term "p53" originates from its identification as a 53 kilodalton protein. The 'p' stands for protein, and the number refers to its molecular mass. This gene was first identified in the 1970s and has since become central to understanding cancer development.Significance in Asbestos Context: In the context of asbestos exposure, mutations in the p53 gene are associated with an increased risk of developing mesothelioma and other asbestos-related cancers. The gene's role in DNA repair and cell cycle regulation makes it a key factor in the body's response to asbestos-induced damage.Example Sentence: Research has shown that asbestos exposure can lead to mutations in the p53 gene, increasing the likelihood of developing mesothelioma.Related Terms: Mesothelioma, Tumor Suppressor Gene, Apoptosis, DNA Repair, Asbestos-Induced CancerNotes: - Mutations in p53 are not exclusive to asbestos exposure but are common in many types of cancer. - The p53 gene is often referred to as the "guardian of the genome."