Term: Phagocytosis
Definition: Phagocytosis is the process by which certain cells, such as macrophages, engulf and digest foreign particles, bacteria, or cellular debris to protect the body and maintain tissue health.
Phonetic Pronunciation: (fag-oh-sy-TOH-sis)
Etymological Origin: The term originates from the Greek words phago (to eat) and kytos (cell), combined with the suffix -osis (process or condition). It was first used in the late 19th century to describe the cellular "eating" process observed under a microscope.
Significance in Asbestos Context: Phagocytosis is significant in the field of asbestos because pulmonary alveolar macrophages (PAMs) attempt to engulf and process inhaled asbestos fibers. However, due to the indestructible nature of asbestos, this process often fails, leading to chronic inflammation, tissue damage, and the development of asbestos-related diseases such as asbestosis, lung cancer, and mesothelioma. Understanding phagocytosis helps explain the biological mechanisms behind asbestos toxicity and its long-term health impacts.
Synonyms or Related Terms: Cellular engulfment, macrophage activity, immune response, endocytosis (related but broader).
Example Sentence: "The inability of macrophages to completely digest asbestos fibers during phagocytosis contributes to the chronic inflammation and scarring seen in asbestosis."
Common Misconceptions:
