Definition:
Platelet-Derived Growth Factor (PDGF) is a protein that regulates cell growth, division, and repair, particularly in connective tissues. It is a key signaling molecule involved in wound healing and tissue regeneration.
Phonetic Pronunciation:
(PLAYT-let duh-RYVD GROH-th FAK-tor)
Etymological Origin:
The term "platelet-derived growth factor" originates from its discovery as a growth factor released by platelets during blood clotting. The word "platelet" comes from the French "plate," meaning flat, and "growth factor" refers to its role in promoting cellular growth and proliferation.
Significance in Asbestos Context:
PDGF is significant in the context of asbestos exposure because it is implicated in the development of asbestos-related diseases, such as asbestosis and mesothelioma. Asbestos exposure can stimulate the release of PDGF from alveolar macrophages and other cells, leading to fibroblast proliferation and excessive collagen production, which are hallmarks of pulmonary fibrosis. Additionally, PDGF can contribute to the growth of mesothelial cells, potentially playing a role in the progression of mesothelioma. Understanding PDGF's role helps researchers and clinicians identify mechanisms of asbestos-induced diseases and explore potential therapeutic interventions.
Synonyms or Related Terms:
Example Sentence:
"Studies have shown that asbestos exposure triggers the release of platelet-derived growth factor, which contributes to the fibrotic changes seen in asbestosis."
Common Misconceptions:
