SV40

Type: Scientific Term

Definition:
SV40 (Simian Virus 40) is a polyomavirus originally discovered in monkeys that has been studied for its potential role in causing cancer in humans, including mesothelioma.

Phonetic Pronunciation:
(ess-vee-FOUR-tee)

Etymological Origin:
The term "SV40" stands for "Simian Virus 40," with "simian" referring to monkeys and "40" indicating that it was the 40th virus discovered in this group. It was first identified in the 1960s as a contaminant in polio vaccines produced using monkey kidney cells.

Significance in Asbestos Context:
SV40 is significant in the field of asbestos-related diseases because some studies have suggested a possible link between the virus and mesothelioma, a cancer strongly associated with asbestos exposure. Research has indicated that SV40 may act as a cofactor, potentially enhancing the carcinogenic effects of asbestos. However, this connection remains controversial and unconfirmed, requiring further investigation. Understanding SV40's role is important for both medical research and legal cases involving asbestos-related diseases.

Synonyms or Related Terms:

  • Simian Virus 40
  • Polyomavirus SV40
  • Oncogenic virus (in the context of its potential cancer-causing properties)

Example Sentence:
"Some researchers have hypothesized that SV40 may contribute to the development of mesothelioma in individuals exposed to asbestos, though this theory remains under debate."

Common Misconceptions:

  • Misconception: SV40 is the primary cause of mesothelioma.
    Clarification: While SV40 has been studied as a potential cofactor in mesothelioma, asbestos exposure is the primary and well-established cause of this disease.
  • Misconception: SV40 contamination is still a widespread issue in vaccines.
    Clarification: SV40 contamination occurred in polio vaccines produced between 1955 and 1963. Modern vaccines are free from SV40 contamination due to improved production methods.
  • Misconception: The link between SV40 and mesothelioma is proven.
    Clarification: The association between SV40 and mesothelioma is not conclusively established and remains a topic of ongoing research.