SV40

Term: SV40Definition: Simian Virus 40 (SV40) is a polyomavirus that has been found in some human tumors and is suspected to play a role in the development of certain cancers, including mesothelioma. It is thought to be a potential cofactor in asbestos-related malignancies.Phonetic Pronunciation: (es-vee-FOHR-tee)Origin: SV40 was first identified in 1960 in rhesus monkey kidney cells used to produce polio vaccines. The name "SV40" stands for "Simian Virus 40," reflecting its discovery in the 40th sample tested from these cells. The virus's potential oncogenic properties were discovered later, sparking extensive research into its role in human diseases.Significance in Asbestos Context: SV40 is significant in asbestos litigation because it may enhance the carcinogenic effects of asbestos fibers. Some studies suggest that exposure to both SV40 and asbestos increases the risk of developing mesothelioma, a cancer strongly linked to asbestos exposure. This dual exposure could be a critical factor in determining liability and compensation in asbestos-related lawsuits.Example Sentence: The plaintiff's attorney argued that the combination of the client's asbestos exposure and infection with SV40 likely contributed to his development of mesothelioma.Related Terms: Mesothelioma, Asbestos, Carcinogen, Polio Vaccine, Oncogenic VirusNotes: - Not all studies confirm a link between SV40 and human cancers, leading to ongoing debate. - SV40 contamination in early polio vaccines is a historical concern but has been addressed in modern vaccine production. - The exact mechanism by which SV40 might enhance asbestos-induced cancer is still under research.