Transforming Growth Factor-beta (TGF-β)

Term: Transforming Growth Factor-beta (TGF-β)Definition: A cytokine that plays a key role in regulating cell growth, proliferation, differentiation, and apoptosis. It is implicated in the pathogenesis of asbestos-related diseases.Phonetic Pronunciation: (trans-FORM-ing GROWTH FAC-tor BAY-ta)Origin: The term "Transforming Growth Factor" was coined due to its initial discovery in the context of its ability to induce transformation in cells. The "beta" designation distinguishes it from other related growth factors. The term is rooted in the scientific nomenclature used to describe biological signaling molecules.Significance in Asbestos Context: TGF-β is significant in asbestos-related diseases because it is involved in the fibrotic processes that lead to conditions like asbestosis and mesothelioma. Its dysregulation can promote the progression of these diseases, making it a potential target for therapeutic intervention.Example Sentence: Research has shown that exposure to asbestos fibers can lead to increased levels of TGF-β, contributing to the development of pulmonary fibrosis.Related Terms: Cytokine, Fibrosis, Asbestosis, Mesothelioma, ApoptosisNotes: - TGF-β has multiple isoforms, with TGF-β1 being the most studied in the context of asbestos-related diseases. - While TGF-β is implicated in disease progression, it also has roles in normal physiological processes.