Definition:
Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine, a protein produced by immune cells, that plays a critical role in inflammation, immune system regulation, and cell death. It is involved in the body's response to injury, infection, and cancer.
Phonetic Pronunciation:
(TOO-mor neh-KROH-sis FAK-tor AL-fuh)
Etymological Origin:
The term "tumor necrosis factor" originates from the Latin word tumor, meaning "swelling," and the Greek word nekrosis, meaning "death." The suffix "alpha" distinguishes this specific cytokine from other related factors. TNF-α was first identified in the 1970s for its ability to cause necrosis (death) of tumor cells in certain experimental models.
Significance in Asbestos Context:
TNF-α is significant in the asbestos context because it is a key mediator in the inflammatory and fibrotic processes caused by asbestos exposure. Research has shown that asbestos fibers can stimulate the release of TNF-α from immune cells, contributing to chronic inflammation, fibrosis, and the development of asbestos-related diseases such as asbestosis and mesothelioma. TNF-α is also being studied as a potential therapeutic target to mitigate the harmful effects of asbestos-induced inflammation and fibrosis.
Synonyms or Related Terms:
Example Sentence:
"Studies have demonstrated that asbestos exposure triggers the release of tumor necrosis factor-alpha, which plays a pivotal role in the development of mesothelioma."
Common Misconceptions:
